Aptevo Therapeutics Inc. announced a significant expansion of its anti-cancer pipeline with the filing of two provisional patents for novel trispecific candidates, APVO452 and APVO451. These next-generation molecules are designed to target prostate cancer and multiple additional solid tumor types with significant unmet needs.
The new candidates harness Aptevo's proprietary ADAPTIR-FLEX™ design, enabling them to simultaneously engage tumor antigens, T cells, and immunosuppressive cells. This advanced multi-targeting approach aims to enhance immune activation and overcome tumor resistance, representing a key R&D initiative.
This pipeline expansion builds on the company's growing suite of CRIS-7-derived, CD3-directed molecules, supported by compelling clinical validation from lead candidate mipletamig. Mipletamig has demonstrated strong clinical safety and efficacy for the treatment of acute myeloid leukemia (AML), underpinning the potential of Aptevo's platform technology.
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