Aptevo Therapeutics Inc. provided additional details about its preclinical bispecific antibody, APVO442, which is being developed to target prostate cancer. APVO442 is designed for enhanced precision tumor targeting and minimized safety risks, aiming to offer a differentiated treatment option for this difficult-to-treat cancer.
The development of APVO442 leverages Aptevo's proprietary ADAPTIR-FLEX® platform, which is central to the company's innovation in antibody engineering. This platform enables the creation of therapeutic candidates with diverse mechanisms of action, addressing complex diseases like advanced prostate cancer.
APVO442 represents the first molecule developed using the cutting-edge ADAPTIR-FLEX platform. Its design focuses on precise tumor targeting and controlled immune activation, which is crucial for limiting systemic toxicity often associated with cancer immunotherapies.
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