On 15 October 2025, Avantor, Inc. announced a strategic partnership with BlueWhale Bio, a commercial‑stage company focused on immune cell therapy manufacturing. The collaboration combines Avantor’s bioprocessing and custom ancillary‑reagent manufacturing capabilities with BlueWhale Bio’s Synecta™ cell‑derived nanoparticle (CDNP) platform, which mimics natural T‑cell stimulation.
The partnership aims to accelerate the scale‑up of CDNP manufacturing to support CAR‑T developers, potentially reducing expansion time and manufacturing variability. Together, the teams will produce GMP‑grade CDNP materials for next‑generation manufacturing approaches, with BlueWhale Bio’s Synecta™ T1 CDNPs already being used in a 3‑day CAR‑T clinical trial. Early data from BlueWhale Bio’s preclinical and clinical programs show earlier cell division, higher cell yields, and fewer process interventions, indicating a significant reduction in CAR‑T process time and cell stress.
CEO Emmanuel Ligner said the alliance reflects Avantor’s commitment to delivering highly relevant manufacturing solutions and enabling next‑generation therapies through innovation, reliability, and scale. He noted that CAR‑T therapies have transformed cancer care, but manufacturing remains a major bottleneck characterized by high cost, variability, and lengthy release cycles. The collaboration is positioned to address these challenges by integrating next‑generation activation and expansion reagents into a GMP‑ready, scalable platform.
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