Anavex Life Sciences Corp. reported a peer-reviewed publication in the journal iScience, titled “Conserved LIR-specific interaction of Sigma-1 receptor and GABARAP.” This publication ascertains the precise autophagy mechanism of sigmar-1 receptor (S1R/SIGMAR1) through blarcamesine activation.
The mechanistic confirmation that blarcamesine restores impaired autophagy through S1R/SIGMAR1 activation by acting upstream of amyloid and tau pathologies at the molecular level was previously established both in vitro and in vivo. This new publication confirms with additional biochemical data the autophagy restoration mechanism of S1R activation with blarcamesine.
The specific S1R-localized motif responsible for physiologically relevant interactions with autophagy proteins—promoting autophagosome biogenesis, autophagic cargo reception, and lysosome fusion—was confirmed and modulated by blarcamesine. This interaction could represent a missing biochemical link in autophagy modulation by S1R, further elucidating blarcamesine's role in countering neurodegeneration.
The content on BeyondSPX is for informational purposes only and should not be construed as financial or investment advice. We are not financial advisors. Consult with a qualified professional before making any investment decisions. Any actions you take based on information from this site are solely at your own risk.