AstraZeneca today announced a strategic collaboration with BostonGene, a developer of a multimodal AI foundation model for tumor and immune biology, to apply the company’s platform to early‑phase oncology trials. The partnership will use BostonGene’s AI system to integrate genomic, transcriptomic, immune, and clinical outcome data, generating predictive insights that can inform patient‑level safety and efficacy expectations and help design safer, more effective therapies from the outset.
BostonGene has raised more than $200 million in funding, including a Series B round in November 2024, and has partnered with several biopharmaceutical companies to accelerate drug discovery. The firm’s “digital twin” platform creates a comprehensive model of a patient’s disease, enabling researchers to simulate treatment responses and identify optimal patient subgroups. AstraZeneca’s use of this technology is expected to shorten development timelines and reduce the risk of late‑stage failures.
The AI platform will be applied across AstraZeneca’s oncology pipeline, with an initial focus on early‑phase studies in solid tumors and immuno‑oncology indications. While the company has not yet disclosed specific pipeline assets, the collaboration is positioned to enhance trial design, improve patient stratification, and accelerate regulatory submissions by providing data‑driven evidence of safety and efficacy earlier in development.
Financial terms of the partnership have not been disclosed. AstraZeneca and BostonGene have agreed to share data and intellectual property under a joint‑development framework, with the expectation that the partnership will generate incremental value for both parties as the platform is integrated into clinical workflows.
Management emphasized the strategic importance of the deal. Jorge Reis‑Folho, Chief of AI for Science Innovation at AstraZeneca, said the collaboration “will enable us to predict which patients will benefit from treatment, helping us design safer, more effective therapies from the start.” Andrew Feinberg, President and CEO of BostonGene, added that the partnership “demonstrates the transformative power of AI‑powered profiling to accelerate oncology development at scale.”
The announcement underscores AstraZeneca’s broader AI strategy, which includes collaborations with Modella AI, Tempus AI, Pathos AI, and Immunai, and reflects the company’s commitment to integrating advanced data science into its R&D pipeline to maintain a competitive edge in precision medicine.
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