AstraZeneca announced a $2 billion investment to expand its manufacturing footprint in Maryland, adding a new state‑of‑the‑art facility in Gaithersburg and enlarging its existing biologics plant in Frederick. The expansion is part of the company’s broader $50 billion U.S. manufacturing and research plan announced in July 2025.
The new Gaithersburg site will double AstraZeneca’s rare‑disease production capacity and will be equipped with advanced artificial‑intelligence and automation technologies to accelerate product development and clinical supply. Both the expanded Frederick plant and the new Gaithersburg facility are expected to be operational by 2029, giving the company a clear timeline for achieving its onshore production goals.
The investment is projected to create approximately 2,600 jobs across the two sites, including 300 highly skilled positions and a range of construction roles. Governor Wes Moore highlighted the project as the largest private capital investment in Maryland in the last decade, underscoring its economic impact on the state’s life‑sciences sector.
CEO Pascal Soriot said the investment “deepens our long‑standing commitment to Maryland – supporting 2,600 jobs, catalyzing economic growth and bringing our extensive rare‑disease portfolio onshore for the first time.” He added that the move strengthens the resilience of the U.S. medicines supply chain and accelerates access to transformative therapies for patients across America and around the world.
AstraZeneca’s Q3 2025 results showed total revenue of $15.19 billion, up 12% year‑over‑year, and reaffirmed its full‑year guidance for high single‑digit revenue growth and low double‑digit core EPS growth. The Maryland expansion aligns with the company’s strategy to capture a larger share of the expanding rare‑disease therapeutics market while leveraging AI to improve manufacturing efficiency.
The investment signals AstraZeneca’s commitment to U.S. manufacturing, supply‑chain resilience, and rare‑disease innovation. By bringing production onshore and integrating cutting‑edge technology, the company positions itself to meet growing demand for rare‑disease therapies and to maintain a competitive edge in a market that rewards operational leverage and rapid product development.
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