Bruker Corporation announced significant advances in ultra-high sensitivity 4D-Proteomics™ with the introduction of the timsUltra AIP mass spectrometer on June 2, 2025, at the 73rd Conference on Mass Spectrometry and Allied Topics (ASMS).
The timsUltra AIP features the innovative Athena Ion Processor (AIP) technology, which further boosts the extreme sensitivity of timsTOF Ultra PASEF® methods. This results in up to 20% gains in protein identifications and up to 35% gains in peptide identifications for high-sensitivity, high-throughput applications with very low sample amounts.
Preliminary data indicates that in combination with the new Evosep Eno nLC system, the timsUltra AIP can deliver over 5000 protein identifications at 250 pg (sample amount of a single HeLa cell) with a throughput of 100 samples per day. This high-throughput capability, combined with ultra-high sensitivity, is a game-changer for applications like single-cell proteomics and immunopeptidomics.
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