Carisma Therapeutics Inc. announced a strategic reprioritization of its pipeline, which includes the cessation of development for CT-0525 and a reduction in its workforce by 34%. These measures are designed to realign resources and focus primarily on advancing the company's in vivo macrophage engineering platform. The platform will target the development of therapies for fibrosis, oncology, and autoimmune diseases.
The decision to discontinue the anti-human epidermal growth factor receptor 2 (anti-HER2) program, CT-0525, follows a comprehensive portfolio review. This strategic shift aims to streamline operations and reduce operating expenses over time, directing investments towards next-generation, high-potential programs that address significant unmet patient needs.
The workforce reduction impacts 34% of employees, reflecting a challenging but necessary step to enhance operational efficiency and reduce operating expenses. Carisma stated that these decisions were made in the best interest of shareholders, with the goal of delivering scalable, next-generation solutions that transform treatment paradigms.
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