CareDx, Inc. and 10x Genomics have announced a strategic collaboration that will launch ImmuneScape™, a multi‑omics research platform designed to decode transplant rejection and drug response. The partnership combines CareDx’s donor‑derived cell‑free DNA (dd‑cfDNA) surveillance technology with 10x Genomics’ single‑cell and spatial biology capabilities, including the Chromium Flex single‑cell and Xenium spatial platforms, to profile immune responses at unprecedented resolution across transplant patients.
The collaboration is positioned to accelerate the development of next‑generation diagnostics and therapeutics. By integrating dd‑cfDNA with high‑resolution single‑cell and spatial profiling, researchers can map the cellular and molecular signatures of rejection in real time, potentially enabling earlier intervention and personalized immunosuppression regimens. CareDx’s CEO, John Hanna, emphasized that ImmuneScape will “translate transplant biology into high‑value patient impact,” while 10x Genomics’ CEO, Serge Saxonov, noted that the partnership opens a new window into the cellular and molecular signatures of rejection that have historically been impossible to measure.
CareDx’s recent Q3 2025 earnings provide a strong backdrop for the partnership. The company reported revenue of $100.1 million, beating expectations of $95.32 million, and an earnings per share of $0.28 versus an anticipated loss of $0.08. The earnings beat was driven by robust demand for its AlloSure and AlloMap products, as well as cost discipline that kept operating expenses in line with revenue growth. The results reinforced CareDx’s position as the only publicly traded company focused exclusively on transplant patient surveillance, a niche that has attracted a growing number of transplant centers in the United States.
While the announcement does not disclose financial terms or a specific launch date for ImmuneScape, the partnership signals a significant strategic shift toward multi‑omics integration. The collaboration expands 10x Genomics’ application of its technologies into the specialized field of transplant medicine, while giving CareDx access to cutting‑edge single‑cell and spatial biology that can deepen its diagnostic portfolio. Analysts view the deal as a potential catalyst for future revenue growth, though the lack of a launch timeline and financial details means the immediate impact on earnings is uncertain.
The partnership also highlights a broader industry trend toward precision medicine in transplantation. By combining non‑invasive dd‑cfDNA monitoring with high‑resolution molecular profiling, ImmuneScape could reduce the need for invasive biopsies, lower healthcare costs, and improve patient outcomes. If successful, the platform could open new market opportunities in organ rejection monitoring, drug response assessment, and personalized immunosuppression, potentially expanding CareDx’s addressable market beyond its current surveillance focus.
The collaboration underscores CareDx’s commitment to maintaining its competitive edge in a niche market. With a strong cash position and low debt, the company is well positioned to invest in research and development. The partnership also aligns with 10x Genomics’ strategy to broaden the reach of its single‑cell and spatial biology platforms, potentially creating cross‑sell opportunities to CareDx’s existing customer base.
Overall, the announcement represents a material development that could reshape the transplant diagnostics landscape, warranting coverage for investors and industry observers.
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