Bright Minds Biosciences Reports Positive Preclinical Findings for BMB-101 in SUDEP Model

DRUG
November 01, 2025

Bright Minds Biosciences Inc. announced on May 13, 2025, positive findings from its DBA/2 mouse model study evaluating BMB-101. The study demonstrated a complete elimination of drop attacks in this preclinical model.

The DBA/2 mouse model is recognized as highly predictive of sudden unexpected death in epilepsy (SUDEP), a severe complication of epilepsy. These findings highlight BMB-101’s potential to address critical gaps in SUDEP prevention.

BMB-101 is a novel scaffold 5-HT2C Gq-protein biased agonist currently in a Phase 2 clinical trial for Absence Epilepsy and Developmental and Epileptic Encephalopathy (DEE). The preclinical results reinforce the therapeutic rationale for BMB-101 in treating severe neurological disorders.

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