Erasca announced that the United States Patent and Trademark Office granted Patent No. 12,458,647 on November 6, 2025 for its pan‑RAS molecular glue ERAS‑0015 and related formulations. The patent protects the composition of matter and associated drug delivery systems until at least September 2043, giving the company a 17‑year exclusivity window that is critical for a first‑in‑class oncology therapy.
The new patent is a cornerstone of Erasca’s intellectual‑property strategy. By securing long‑term protection for ERAS‑0015, the company solidifies its competitive moat in the RAS/MAPK pathway space, where few therapies have achieved pan‑RAS activity. The exclusivity period also enhances Erasca’s attractiveness to potential partners and investors, as it signals a durable commercial opportunity for a best‑in‑class treatment that could address a broad spectrum of KRAS‑driven cancers.
CEO Jonathan E. Lim emphasized that the patent “is a foundational milestone for our ERAS‑0015 program, further highlighting our efficient execution since in‑licensing the program in May 2024.” He added that the patent is part of a series of filings designed to build a robust IP portfolio for the company’s RAS‑targeting franchise, and that initial Phase 1 monotherapy data for both ERAS‑0015 and its sister program ERAS‑4001 are expected in 2026.
Erasca’s financial position supports continued investment in its pipeline. As of June 30, 2025, the company held $386.7 million in cash and equivalents, providing a runway that extends into the second half of 2028. Both ERAS‑0015 and ERAS‑4001 received IND clearance in May 2025 and June 2025, respectively, ahead of schedule, positioning the company to move quickly into clinical development.
The patent issuance reinforces Erasca’s strategic focus on developing a best‑in‑class pan‑RAS therapy. With a strong IP foundation, ample cash reserves, and a clear clinical roadmap, the company is well positioned to advance ERAS‑0015 toward regulatory approval and to capture a significant share of the growing RAS‑driven oncology market.
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