Esperion Therapeutics reported preliminary full‑year 2025 results that show U.S. net product sales of $156 million to $160 million, a 35% to 38% increase from the $115.7 million recorded in 2024. Total revenue for the year rose to $400 million to $408 million, up 20% to 23% from $332.3 million in 2024.
The growth was driven by robust demand for the company’s oral non‑statin therapies, NEXLETOL and NEXLIZET, as more physicians prescribe these products to patients who cannot tolerate statins. Expanded prescriber adoption, coupled with increased international royalties—particularly from Daiichi Sankyo Europe—contributed to the revenue lift. A Royalty Purchase Agreement with OMERS Life Sciences brought in approximately $304.7 million in cash, further supporting the top‑line expansion.
Management highlighted that 2025 was the most successful year in Esperion’s history and that the company is on track to achieve sustainable operating profitability beginning in the first quarter of 2026. CEO Sheldon Koenig emphasized that the results “set the stage for something far bigger: Vision 2040,” a long‑term strategy to transform Esperion into a multi‑product, innovation‑driven global pharmaceutical company.
Analysts reacted positively to the earnings, citing the strong sales momentum and the clear trajectory toward profitability. The market welcomed the company’s ability to capture a growing statin‑intolerant market and the confidence expressed by management in the 2026 outlook.
The results also underscore Esperion’s strategic positioning: the company’s core products are protected by patent settlements that delay generic competition until at least April 2040, and inclusion in U.S. guideline recommendations is expected early in 2026, which should further accelerate adoption.
While the preliminary release did not include detailed guidance or earnings per share, the revenue growth and profitability trajectory signal strong confidence in the company’s commercial strategy and pipeline development.
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