Pfizer's global withdrawal of its sickle cell disease drug, Oxbryta, has created a significant void in the market. This development increases the demand for new oral therapeutic options for patients with sickle cell disease.
Fulcrum Therapeutics' lead clinical-stage asset, pociredir, is an oral small molecule in development for sickle cell disease. The competitive landscape for sickle cell disease therapies is rapidly evolving, and this withdrawal positions pociredir more favorably.
The high unmet need for oral therapies in sickle cell disease, coupled with the removal of a key competitor, enhances the potential market opportunity for pociredir as it advances through clinical development.
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