Nurix Therapeutics presented data from a phase I/II study of its Bruton’s tyrosine kinase degrader, bexobrutideg (NX‑5948), at the 67th American Society of Hematology (ASH) Annual Meeting. In 31 patients with relapsed or refractory Waldenström macroglobulinemia, the drug achieved a 75.0 % objective response rate, comprising 14 partial responses and three very good partial responses. No dose‑limiting toxicities were observed, and the safety profile was described as favorable. The median follow‑up of 8.1 months was reported, and neither median duration of response nor progression‑free survival had been reached, indicating durable activity in the responding cohort.
The clinical significance of these findings is amplified by the heavily pre‑treated nature of the population, which included patients harboring MYD88 and CXCR4 mutations—genetic alterations that can influence response to standard BTK inhibitors. Responses were observed regardless of mutation status, suggesting that bexobrutideg’s mechanism as a BTK degrader may overcome resistance mechanisms that limit current therapies. The high ORR in this difficult‑to‑treat group positions the drug as a promising candidate for regulatory approval and could reshape the therapeutic landscape for Waldenström macroglobulinemia.
While the trial results are encouraging, Nurix’s broader financial picture remains a key context. In the third quarter of 2025, the company reported a revenue miss and an earnings‑per‑share shortfall, driven by the conclusion of a research term with Sanofi and increased R&D spending on clinical and manufacturing activities. The company’s cash position remains substantial, but the burn rate has accelerated as it invests in pivotal studies for bexobrutideg in chronic lymphocytic leukemia and other B‑cell malignancies. These financial dynamics underscore the importance of translating clinical milestones into commercial success.
Chief Medical Officer Paula G. O’Connor highlighted that the data “continue to demonstrate encouraging activity of bexobrutideg with durable and deepening responses with longer time on treatment” and that the drug was “well tolerated.” CEO Arthur T. Sands emphasized confidence in the program’s potential, noting that the trial outcomes support the company’s strategy to advance bexobrutideg through the development pipeline and to pursue regulatory submissions in multiple indications.
The trial’s positive outcomes strengthen Nurix’s pipeline narrative, but the company must navigate the financial headwinds of high R&D costs and a competitive market for BTK‑targeted therapies. Successful regulatory approval and subsequent commercialization of bexobrutideg could provide a new revenue stream that offsets current earnings shortfalls and positions Nurix as a leader in targeted B‑cell malignancy treatment. Investors and stakeholders will watch how the company leverages these clinical gains to achieve commercial traction while managing its cash burn and pursuing additional indications.
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