On June 22, 2025, Novo Nordisk presented results from the Phase IIIb FRONTIER5 trial, showing that a direct switch to investigational Mim8 (denecimig) prophylaxis treatment from emicizumab was well-tolerated in adults and adolescents with hemophilia A. The switch occurred without a washout period or Mim8 loading dose.
The data indicated no safety concerns and a sustained increase in thrombin generation into the normal range, without causing thrombotic risk. This positive outcome supports Mim8 as a promising new treatment option for hemophilia A patients.
Furthermore, a Patient-Reported Outcomes (PROs) assessment found the Mim8 pen-injector easy to use, with strong user preference. This enhances the potential for patient adherence and overall market acceptance for this rare disease drug.
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