Sanofi completed its acquisition of Vicebio Ltd. on December 4 2025, paying up to $1.6 billion—$1.15 billion in cash and up to $450 million in milestone payments—thereby adding Vicebio’s early‑stage RSV/HMPV combination vaccine candidate to its portfolio.
Vicebio’s proprietary Molecular Clamp technology stabilizes viral proteins in their prefusion conformation, enabling non‑mRNA, liquid, multivalent vaccines that can be stored at 2–8 °C. The technology offers a scalable, shelf‑stable alternative to mRNA platforms and positions Sanofi to develop next‑generation respiratory vaccines more rapidly.
The deal aligns with Sanofi’s strategy to strengthen its immunology and vaccine businesses. By acquiring a non‑mRNA RSV platform, Sanofi can broaden its product mix, compete more effectively against GSK, Pfizer, and Moderna, and accelerate the development of combination vaccines for RSV and human metapneumovirus.
Sanofi’s recent financial performance underscores the strategic fit: Q4 2024 adjusted earnings were $0.70 per share, net sales rose 9.1 % to $11.27 billion, and Q3 2025 sales reached €12.434 billion, up from €12.157 billion. Dupixent continues to drive immunology revenue, while vaccine sales remain modest due to a softer flu market.
CEO Paul Hudson highlighted that the acquisition is part of a broader transformation toward a science‑driven biopharma company, leveraging AI and R&D investment to build a robust pipeline. The addition of Vicebio’s technology is expected to enhance Sanofi’s competitive positioning without materially impacting its 2025 financial guidance.
The acquisition is a material event that could reshape Sanofi’s vaccine portfolio and market share in the RSV space, warranting high importance for investors.
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