Instil Bio Announces First Patient Dosed in China Phase 1b/2 Trial for IMM2510/SYN-2510 in NSCLC

TIL
October 06, 2025

Instil Bio, Inc. announced significant clinical progress for IMM2510/SYN-2510 in China, with its collaborator ImmuneOnco Biopharmaceuticals. ImmuneOnco reported that the first patient has been dosed in its Phase 1b/2 clinical trial evaluating IMM2510/SYN-2510 in combination with chemotherapy for patients with advanced non-small cell lung cancer (NSCLC). This trial plans to enroll first-line patients.

ImmuneOnco anticipates presenting initial clinical data from this trial, including data for first-line NSCLC patients, as early as the second half of 2025. This data is expected to be valuable in advancing the development of IMM2510/SYN-2510 in NSCLC.

Instil also stated its plan to target enrollment of first-line NSCLC patients in a potential initial U.S. clinical trial of SYN-2510/IMM2510 combined with chemotherapy. This U.S. trial is expected to initiate in the second half of 2025, contingent upon obtaining the necessary regulatory approvals.

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